Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling.

@article{Pratt2000CuttingEG,
  title={Cutting edge: gab2 mediates an inhibitory phosphatidylinositol 3'-kinase pathway in T cell antigen receptor signaling.},
  author={Joanne Pratt and Vivien E. Igras and Hiroyuki Maeda and Shairaz Baksh and Erwin W. Gelfand and S J Burakoff and Benjamin G Neel and Hua Gu},
  journal={Journal of immunology},
  year={2000},
  volume={165 8},
  pages={4158-63}
}
Phosphatidylinositol 3'-kinase (PI3K) is a key component of multiple signaling pathways, where it typically promotes survival, proliferation, and/or adhesion. Here, we show that in TCR signaling, the scaffolding adapter Gab2 delivers an inhibitory signal via PI3K. Overexpression of Gab2 in T cell lines inhibits TCR-evoked activation of the IL-2 promoter, blocking NF-AT- and NF-kappaB-directed transcription. Inhibition is abrogated by mutating the Gab2 p85-binding sites, by treatment with PI3K… CONTINUE READING

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