Cutting edge: extracellular signal-regulated kinases 1/2 function as integrators of TCR signal strength.

@article{Schade2004CuttingEE,
  title={Cutting edge: extracellular signal-regulated kinases 1/2 function as integrators of TCR signal strength.},
  author={Andrew E. Schade and Alan D. Levine},
  journal={Journal of immunology},
  year={2004},
  volume={172 10},
  pages={5828-32}
}
Altered signaling through the TCR is currently showing promise for immunotherapy. However, the molecular mechanisms are not completely understood. Therefore, we investigated whether varying the strength of TCR engagement in various human T cells would yield different second messenger responses. The kinetics and duration of extracellular signal-regulated kinase (ERK) activation, central to multiple cellular responses, are distinctly dependent on the T cell activation state (naive vs effector… CONTINUE READING