Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.

@article{Lim2005CuttingED,
  title={Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.},
  author={Hyung Woo Lim and Peter J Hillsamer and Allison H. Banham and Chang H Kim},
  journal={Journal of immunology},
  year={2005},
  volume={175 7},
  pages={4180-3}
}
Regulatory T cells (Tregs) can potentially migrate to the B cell areas of secondary lymphoid tissues and suppress T cell-dependent B cell Ig response. T cell-dependent Ig response requires B cell stimulation by Th cells. It has been unknown whether Tregs can directly suppress B cells or whether they must suppress Th cells to suppress B cell response. We report here that Foxp3+ Tregs are found in T-B area borders and within germinal centers of human lymphoid tissues and can directly suppress B… CONTINUE READING

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