Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.

@article{Eigenbrod2008CuttingEC,
  title={Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.},
  author={Tatjana Eigenbrod and Jong-Hwan Park and J{\"u}rgen Harder and Yoichiro Iwakura and Gabriel N{\'u}{\~n}ez},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={
          8194-8
        }
}
Endogenous danger signals released from necrotic cells are thought to be sensed by phagocytes leading to secretion of IL-1alpha and neutrophilic recruitment. However, the mechanisms for IL-1alpha production and IL-1alpha-mediated sterile inflammation remain poorly understood. We report here that necrotic cell extracts elicited little secretion of CXCL1 and IL-6 from macrophages but robust production in mesothelial cells. The induction of CXCL1 as well as activation of NF-kappaB and MAPKs by… CONTINUE READING

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Cutting edge : critical role for mesothelial cells in necrosis - induced inflammation through the recognition of IL-1 alpha released from dying cells .
Cutting edge : critical role for mesothelial cells in necrosis - induced inflammation through the recognition of IL-1 alpha released from dying cells .
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