Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria.

@article{deWalick2007CuttingEC,
  title={Cutting edge: conventional dendritic cells are the critical APC required for the induction of experimental cerebral malaria.},
  author={Saskia deWalick and Fiona H Amante and Karli A. McSweeney and Louise M. Randall and Amanda C. Stanley and Ashraful Haque and Rachel D Kuns and Kelli P A Macdonald and Geoff R. Hill and Christian R Engwerda},
  journal={Journal of immunology},
  year={2007},
  volume={178 10},
  pages={6033-7}
}
Cerebral malaria (CM) is a serious complication of Plasmodium falciparum infection, causing significant morbidity and mortality among young children and nonimmune adults in the developing world. Although previous work on experimental CM has identified T cells as key mediators of pathology, the APCs and subsets therein required to initiate immunopathology remain unknown. In this study, we show that conventional dendritic cells but not plasmacytoid dendritic cells are required for the induction… CONTINUE READING

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