Cutting edge: class I presentation of host peptides following HIV infection.

@article{Hickman2003CuttingEC,
  title={Cutting edge: class I presentation of host peptides following HIV infection.},
  author={Heather D Hickman and Angela D. Luis and Wilfried Bardet and Rico Buchli and Casey L. Battson and Michael H. Shearer and Kenneth W. Jackson and Ronald C. Kennedy and William H. Hildebrand},
  journal={Journal of immunology},
  year={2003},
  volume={171 1},
  pages={
          22-6
        }
}
Class I MHC molecules bind intracellular peptides for presentation to cytotoxic T lymphocytes. Identification of peptides presented by class I molecules during infection is therefore a priority for detecting and targeting intracellular pathogens. To understand which host-encoded peptides distinguish HIV-infected cells, we have developed a mass spectrometric approach to characterize HLA-B*0702 peptides unique to or up-regulated on infected T cells. In this study, we identify 15 host proteins… CONTINUE READING

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