Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster.

@article{Takemoto2000CuttingEC,
  title={Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster.},
  author={Naofumi Takemoto and Yumiko Kamogawa and H Jun Lee and Hirokazu Kurata and Ken‐ichi Arai and Anne O'Garra and Naoko Arai and Shoichiro Miyatake},
  journal={Journal of immunology},
  year={2000},
  volume={165 12},
  pages={6687-91}
}
During the differentiation of naive Th cells into Th2 effector cells, the entire IL-4/IL-13 locus is remodeled into an accessible chromatin conformation. Here we show that ectopic expression and activation of Stat6 or GATA-3 in Th cells developing under Th1-polarizing conditions lead to the induction of chromatin remodeling not only at the flanking regions of the IL-4 and IL-13 genes but also at the IL-4/IL-13 intergenic regulatory region for the IL-4/IL-13/IL-5 gene cluster. Furthermore, we… CONTINUE READING