Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.

@article{Zhang2013CuttingEA,
  title={Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRγ deficiency.},
  author={Tianxiang Zhang and Jeannine M. Scott and Ilwoong Hwang and Sungjin Kim},
  journal={Journal of immunology},
  year={2013},
  volume={190 4},
  pages={1402-6}
}
Because NK cells lack gene-recombination machinery and are thought to be relatively short-lived, it is unclear whether NK cells can mount long-term effective recall responses to reinfections by diverse pathogens. In this article, we report that FcRγ-deficient NK cells, which we recently identified and termed g(-)NK cells, possess distinct memory features directed by FcR-mediated Ab-dependent target recognition. The presence of g(-)NK cells was associated with prior human CMV (HMCV) infection… CONTINUE READING