Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.

  title={Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance.},
  author={Lu{\'i}s Afonso Graça and Karen Honey and Elizabeth Adams and Stephen Paul Cobbold and Herman Waldmann},
  journal={Journal of immunology},
  volume={165 9},
Nondepleting anti-CD154 (CD40 ligand) mAbs have proven effective in inducing transplantation tolerance in rodents and primates. In the induction phase, anti-CD154 Ab therapy is known to enhance apoptosis of Ag reactive T cells. However, this may not be the sole explanation for tolerance, as we show in this study that tolerance is maintained through a dominant regulatory mechanism which, like tolerance induced with CD4 Abs, manifests as infectious tolerance. Therefore, tolerance induced with… CONTINUE READING

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