Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus.

  title={Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus.},
  author={Junxiang Zhang and Viktor V. Roschke and Kevin P. Baker and Zhengqi Wang and Graciela S Alarc{\'o}n and Barri J. Fessler and Herv{\'e} Bastian and Robert Kimberly and Tingting Zhou},
  journal={Journal of immunology},
  volume={166 1},
Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic autoimmunity in animal models of spontaneous autoimmune disease, and transgenic animals expressing BLyS develop typical autoimmune disease. Here, we demonstrate significant elevations of BLyS in the patients with systemic lupus erythematosus (SLE). The BLyS isolated from the sera of SLE patients had the same m.w. as the natural soluble form and was able to stimulate B cell activation in vitro. Increased BLyS in SLE… CONTINUE READING
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