Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus.

@article{Benedict1999CuttingEA,
  title={Cutting edge: a novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus.},
  author={Chris A Benedict and Kris D. Butrovich and Nell S. Lurain and Jacques Corbeil and Isabelle A Rooney and P Schneider and Jurg Tschopp and Carl F Ware},
  journal={Journal of immunology},
  year={1999},
  volume={162 12},
  pages={6967-70}
}
The UL144 open reading frame found in clinical isolates of human CMV (HCMV) encodes a structural homologue of the herpesvirus entry mediator, a member of the TNFR superfamily. UL144 is a type I transmembrane glycoprotein that is expressed early after infection of fibroblasts; however, it is retained intracellularly. A YXXZ motif in the highly conserved cytoplasmic tail contributes to UL144 subcellular distribution. The finding that no known ligand of the TNF family binds UL144 suggests that its… CONTINUE READING

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