Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines.

@article{Supajatura2002CuttingEV,
  title={Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines.},
  author={Volaluck Supajatura and Hiroko Ushio and Akihiro Wada and Kinnosuke Yahiro and Ko Okumura and Hideoki Ogawa and Toshiya Hirayama and Chisei Ra},
  journal={Journal of immunology},
  year={2002},
  volume={168 6},
  pages={2603-7}
}
Mucosal mast cells strategically located at the optimal site interact with invading bacteria. Presence of VacA, the virulent Helicobacter pylori cytotoxin, is correlated with the severity of H. pylori-induced gastritis. To examine the mechanisms of inflammation in H. pylori-induced gastritis, we administered VacA to the mice. Inoculation of VacA resulted in epithelium vacuolization and marked infiltrations of mast cells and mononuclear cells into the mucosal epithelium within 24 h. In an in… CONTINUE READING