Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

@article{Banerjee2010CuttingET,
  title={Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.},
  author={Arnob Banerjee and Scott Michael Gordon and Andrew M Intlekofer and Michael A. Paley and Erin C. Mooney and Tulia Lindsten and Elaine Wherry and Steven L Reiner},
  journal={Journal of immunology},
  year={2010},
  volume={185 9},
  pages={4988-92}
}
CD8(+) T cells responding to intracellular infection give rise to cellular progeny that become terminally differentiated effector cells and self-renewing memory cells. T-bet and eomesodermin (Eomes) are key transcription factors of cytotoxic lymphocyte lineages. We show in this study that CD8(+) T cells lacking Eomes compete poorly in contributing to the pool of Ag-specific central memory cells. Eomes-deficient CD8(+) T cells undergo primary clonal expansion but are defective in long-term… CONTINUE READING
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