Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.

@article{Zhang2005CuttingET,
  title={Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.},
  author={Xuchen Zhang and Peiying Shan and Salman T Qureshi and Robert Homer and Ruslan Medzhitov and Paul W. Noble and Patty J Lee},
  journal={Journal of immunology},
  year={2005},
  volume={175 8},
  pages={4834-8}
}
TLRs have been studied extensively in pathogen-mediated host responses. We use a murine model of lethal oxidant-mediated injury to demonstrate for the first time that mammalian TLR4 is required for survival and lung integrity. Administering high levels of inspired oxygen, or hyperoxia, is commonly used as a life-sustaining measure in critically ill patients… CONTINUE READING