Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.

@article{Dumoutier2001CuttingES,
  title={Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.},
  author={Laure Dumoutier and Caroline Leemans and Diane Lejeune and Sergei V. Kotenko and Jean-Christophe Renauld},
  journal={Journal of immunology},
  year={2001},
  volume={167 7},
  pages={3545-9}
}
IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far. Here, we show that mda-7 and IL-19 bind to the previously described IL-20R complex, composed by cytokine receptor family 2-8/IL-20Ralpha and DIRS1/IL-20Rbeta (type I IL-20R). In addition, mda… CONTINUE READING
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