Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation.

@article{Woo2002CuttingER,
  title={Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation.},
  author={Edward Y. Woo and H. -Sh. Yeh and Christina S. Chu and Katia Schlienger and Richard G Carroll and James L Riley and Larry Robert Kaiser and Carl H June},
  journal={Journal of immunology},
  year={2002},
  volume={168 9},
  pages={4272-6}
}
Active suppression by T regulatory cells plays an important role in the down-regulation of T cell responses to foreign and self-Ags. Thus far, the potential role of CD4(+)CD25(+) T cells in human tumors has not been reported. In this work we show that lung tumors contain large numbers of these cells and that they have constitutive high-level expression of CD152 (CTLA-4). Furthermore, the CD4(+)CD25(+) T cells mediate potent inhibition of autologous T cell proliferation. Finally, regulatory T… CONTINUE READING
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