Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.

@article{Ferrer2010CuttingER,
  title={Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.},
  author={Ivana R. Ferrer and Maylene E. Wagener and Jennifer M. Robertson and Alexa P. Turner and Koichi Araki and Rafi Ahmed and Allan D. Kirk and Christian P Larsen and Mandy L Ford},
  journal={Journal of immunology},
  year={2010},
  volume={185 4},
  pages={2004-8}
}
Recent evidence demonstrating that exposure to rapamycin during viral infection increased the quantity and quality of Ag-specific T cells poses an intriguing paradox, because rapamycin is used in transplantation to dampen, rather than enhance, donor-reactive T cell responses. In this report, we compared the effects of rapamycin on the Ag-specific T cell response to a bacterial infection versus a transplant. Using a transgenic system in which the Ag and the responding T cell population were… CONTINUE READING