Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.

Abstract

One-third of the world's population is infected with Mycobacterium tuberculosis (Mtb), and three million people die of tuberculosis each year. Following its ingestion by macrophages (MPs), Mtb inhibits the maturation of its phagosome, preventing progression to a bactericidal phagolysosome. Phagocytosis of Mtb is uncoupled from the elevation in MP cytosolic… (More)

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Cite this paper

@article{Malik2003CuttingEM, title={Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase.}, author={Zulfiqar Ali Malik and Christopher Thompson and Samad Hashimi and Brandon B. Porter and Shankar Subramanian Iyer and David J. Kusner}, journal={Journal of immunology}, year={2003}, volume={170 6}, pages={2811-5} }