Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.

@article{Laroux2005CuttingEM,
  title={Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria.},
  author={F. Stephen Laroux and Xavier Romero and Lee Wetzler and Pablo Engel and Cox Terhorst},
  journal={Journal of immunology},
  year={2005},
  volume={175 9},
  pages={5596-600}
}
MyD88 is an adaptor protein for the TLR family of proteins that has been implicated as a critical mediator of innate immune responses to pathogen detection. In this study, we report that MyD88 plays a crucial role in killing Gram-negative bacteria by primary macrophages via influencing NADPH oxidase function. Peritoneal macrophages from MyD88-/- mice exhibited a marked inability to kill Escherichia coli (F18) or an attenuated strain of Salmonella typhimurium (sseB) in vitro. This defect in… CONTINUE READING

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