Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.

@article{Chang2008CuttingEL,
  title={Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.},
  author={Sun-Young Chang and Hye-Ran Cha and Osamu Igarashi and Paul D. Rennert and Adrien Kissenpfennig and Bernard Malissen and Masanobu Nanno and Hiroshi Kiyono and Mu Sung Kweon},
  journal={Journal of immunology},
  year={2008},
  volume={180 7},
  pages={
          4361-5
        }
}
Topical transcutaneous immunization (TCI) presents many clinical advantages, but its underlying mechanism remains unknown. TCI induced Ag-specific IgA Ab-secreting cells expressing CCR9 and CCR10 in the small intestine in a retinoic acid-dependent manner. These intestinal IgA Abs were maintained in Peyer's patch-null mice but abolished in the Peyer's patch- and lymph node-null mice. The mesenteric lymph node (MLN) was shown to be the site of IgA isotype class switching after TCI. Unexpectedly… CONTINUE READING
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