Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.

@article{Pot2009CuttingEI,
  title={Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.},
  author={Caroline Pot and Hulin Jin and Amit Awasthi and Sue Min Liu and Chen-Yen Lai and Rajat Madan and Arlene H Sharpe and Christopher L. Karp and S C Miaw and I -Ching Ho and Vijay K Kuchroo},
  journal={Journal of immunology},
  year={2009},
  volume={183 2},
  pages={797-801}
}
IL-27 has recently been identified as a differentiation factor for the generation of IL-10-producing regulatory type 1 (Tr1) T cells. However, how IL-27 induces the expansion of Tr1 cells has not been elucidated. In this study we demonstrate that IL-27 drives the expansion and differentiation of IL-10-producing murine Tr1 cells by inducing three key elements: the transcription factor c-Maf, the cytokine IL-21, and the costimulatory receptor ICOS. IL-27-driven c-Maf expression transactivates IL… CONTINUE READING
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