Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease.

@article{Harris2008CuttingEI,
  title={Cutting edge: IL-1 controls the IL-23 response induced by gliadin, the etiologic agent in celiac disease.},
  author={K M Harris and Alessio Fasano and Dean L. Mann},
  journal={Journal of immunology},
  year={2008},
  volume={181 7},
  pages={4457-60}
}
IL-23 has been implicated in the pathogenesis of several tissue-specific autoimmune diseases. Currently, celiac disease (CD) is the only autoimmune disease in which both the major genetic (95% HLA-DQ2(+)) and etiologic factors (dietary glutens) for susceptibility are known. We demonstrate that wheat gliadin induces significantly greater production of IL-23, IL-1beta, and TNF-alpha in PBMC from CD patients compared with HLA-DQ2(+) healthy controls, strongly advocating a role for IL-23 in the… CONTINUE READING

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