Cutting edge: Hierarchy of maturity of murine memory B cell subsets.

  title={Cutting edge: Hierarchy of maturity of murine memory B cell subsets.},
  author={Mary M. Tomayko and Natalie C. Steinel and Shannon M. Anderson and Mark J. Shlomchik},
  journal={Journal of immunology},
  volume={185 12},
The paucity of murine memory B cell markers has been a significant impediment to the study of memory. The most commonly used marker is IgG, which is neither sensitive nor specific, because activated nonmemory cells can be IgG(+), and memory cells can be IgM(+). In this article, we show that, together, PD-L2 (CD273), CD80, and CD73 define at least five phenotypic subsets of murine memory B cells. These subsets are generated from naive cells bearing a single BCR in response to a single T… CONTINUE READING

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