Cutting edge: FasL(+) immune cells promote resolution of fibrosis.

  title={Cutting edge: FasL(+) immune cells promote resolution of fibrosis.},
  author={Shulamit B Wallach-Dayan and Liron Elkayam and Regina Golan-Gerstl and Jenya Konikov and Philip D. Zisman and Mark Richter Dayan and Nissim Arish and Raphael Breuer},
  journal={Journal of autoimmunity},
Immune cells, particularly those expressing the ligand of the Fas-death receptor (FasL), e.g. cytotoxic T cells, induce apoptosis in 'undesirable' self- and non-self-cells, including lung fibroblasts, thus providing a means of immune surveillance. We aimed to validate this mechanism in resolution of lung fibrosis. In particular, we elucidated whether FasL(+) immune cells possess antifibrotic capabilities by induction of FasL-dependent myofibroblast apoptosis and whether antagonists of membrane… CONTINUE READING
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