Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.

@article{Guittard2009CuttingED,
  title={Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.},
  author={Geoffrey Guittard and Audrey G{\'e}rard and Sophie Dupuis-Coronas and H{\'e}l{\`e}ne Tronch{\`e}re and Eva Mortier and C{\'e}dric Favre and Daniel Olive and Pascale Zimmermann and Bernard Payrastre and Jacques A Nun{\`e}s},
  journal={Journal of immunology},
  year={2009},
  volume={182 7},
  pages={
          3974-8
        }
}
Downstream of tyrosine kinase (Dok) proteins Dok-1 and Dok-2 are involved in T cell homeostasis maintenance. Dok protein tyrosine phosphorylation plays a key role in establishing negative feedback loops of T cell signaling. These structurally related adapter molecules contain a pleckstrin homology (PH) domain generally acting as a lipid/protein-interacting module. We show that the presence of this PH domain is necessary for the tyrosine phosphorylation of Dok proteins and their negative… CONTINUE READING
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