Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency.

@article{Cohen2006CuttingED,
  title={Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency.},
  author={Aileen Cleary Cohen and Kari Christine Nadeau and Wenwei Tu and Vivian Hwa and Kira Y Dionis and Liliana Bezrodnik and Alejandro Manuel Teper and Maria Gaillard and Juan Jorge Heinrich and Alan M. Krensky and Ron G. Rosenfeld and David B Lewis},
  journal={Journal of immunology},
  year={2006},
  volume={177 5},
  pages={2770-4}
}
We show that STAT5b is important for the in vivo accumulation of CD4+ CD25(high) T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4+ CD25(high) T cells. STAT5b(A630P/A630P) CD4+ CD25(high) T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4+ CD25- T cells. Expression of CD25, a component of the high-affinity IL-2R, was also… CONTINUE READING

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