Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.

@article{Ying2010CuttingEC,
  title={Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.},
  author={Haiyan Ying and Lifen Yang and Guilin Qiao and Zhenping Li and Li Zhong Zhang and Fei Yin and Dong Xie and Jian Zhang},
  journal={Journal of immunology},
  year={2010},
  volume={185 3},
  pages={
          1375-8
        }
}
Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of… CONTINUE READING

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