Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells.

@article{Schueler2003CuttingEC,
  title={Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells.},
  author={Thomas R. Schueler and Thomas Blankenstein},
  journal={Journal of immunology},
  year={2003},
  volume={170 9},
  pages={
          4427-31
        }
}
  • Thomas R. Schueler, Thomas Blankenstein
  • Published in Journal of immunology 2003
  • Biology, Medicine
  • CD8(+) effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived peptides bound to MHC class I molecules. In addition, tumor-derived Ags can be cross-presented to CD8(+) effector T cells by APCs. IFN-gamma production by CD8(+) T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8(+) T cells secrete IFN-gamma in response to Ag recognition on tumor cells or APCs and 2) whether IFN-gamma mediates its antitumor… CONTINUE READING

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