Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.

@article{Mackay2015CuttingEC,
  title={Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention.},
  author={Laura K Mackay and Asolina Braun and Bethany L. Macleod and Nicholas S. Collins and Christina Tebartz and Sammy Bedoui and Francis Robert Carbone and Thomas Gebhardt},
  journal={Journal of immunology},
  year={2015},
  volume={194 5},
  pages={2059-63}
}
Tissue-resident memory T cells provide local immune protection in barrier tissues, such as skin and mucosa. However, the molecular mechanisms controlling effector T cell retention and subsequent memory formation in those locations are not fully understood. In this study, we analyzed the role of CD69, an early leukocyte activation marker, in regulating effector T cell egress from peripheral tissues. We provide evidence that CD69 surface expression by skin-infiltrating CD8 T cells can be… CONTINUE READING
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