Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo.

@article{Wang2003CuttingEC,
  title={Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo.},
  author={J E Wang and Alexandra M. Livingstone},
  journal={Journal of immunology},
  year={2003},
  volume={171 12},
  pages={6339-43}
}
Recent studies have shown that CD4(+) T cell help is required for the generation of memory CD8(+) T cells that can proliferate and differentiate into effector cells on Ag restimulation. The importance of help for primary CD8(+) T cell responses remains controversial. It has been suggested that help is not required for the initial proliferation and differentiation of CD8(+) T cells in vivo and that classical models of helper-dependent responses describe impaired secondary responses to Ag in… CONTINUE READING

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A role for CD 40 expression on CD 8  T cells in the generation of CD 8  T cell memory

B. Rocha, C. Tanchot
Science • 2002

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