Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.

@article{Wang2009CuttingEC,
  title={Cutting edge: CD28 engagement releases antigen-activated invariant NKT cells from the inhibitory effects of PD-1.},
  author={Jianxiong Wang and L O Cheng and Zenebech Wondimu and Mark Swain and Pere Santamaria and Yang Yang},
  journal={Journal of immunology},
  year={2009},
  volume={182 11},
  pages={6644-7}
}
Costimulatory and coinhibitory signals are important for the maintenance of immune homeostasis both in the steady state and during immune responses. In this study, we explore the relative contributions of these signals to the rapid production of large amounts of cytokines by activated invariant NKT cells (iNKT cells). We find that upon antigenic stimulation… CONTINUE READING