Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.

@article{Williams2002CuttingEA,
  title={Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.},
  author={Richard O Williams},
  journal={Journal of immunology},
  year={2002},
  volume={168 11},
  pages={5392-6}
}
A-kinase anchor proteins (AKAPs) target protein kinase A (PKA) to different subcellular locations and are thought to play important roles in the cAMP signaling pathway. The aims of this study were to determine whether T cells express AKAPs and, if so, to establish their physiological significance. CD4(+) T cells were found to express eight AKAPs. Disruption of the AKAP-PKA interaction caused high levels of IL-2, IL-4, IL-5, and IFN-gamma production in the absence of stimulation via CD3epsilon… CONTINUE READING
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