Cutting Edge : Essential Role of Hypoxia Inducible Factor-1 in Development of Lipopolysaccharide-Induced Sepsis 1

@inproceedings{Peyssonnaux2007CuttingE,
  title={Cutting Edge : Essential Role of Hypoxia Inducible Factor-1 in Development of Lipopolysaccharide-Induced Sepsis 1},
  author={Carole Peyssonnaux and Pilar Cejudo-Mart{\'i}n and Andrew Doedens and Annelies Sophie Zinkernagel and Randall S Johnson and Victor Nizet},
  year={2007}
}
Sepsis, the leading cause of death in intensive care units, reflects a detrimental host response to infection in which bacteria or LPS act as potent activators of immune cells, including monocytes and macrophages. In this report, we show that LPS raises the level of the transcriptional regulator hypoxia-inducible factor-1 (HIF-1 ) in macrophages, increasing… CONTINUE READING