Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells

@article{Zhang2017CuttingEN,
  title={Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells},
  author={Kangning Zhang and X. Xu and M. Pasha and C. Siebel and Angelica Costello and A. Haczku and K. MacNamara and T. Liang and J. Zhu and A. Bhandoola and I. Maillard and Qi Yang},
  journal={The Journal of Immunology},
  year={2017},
  volume={198},
  pages={1798 - 1803}
}
The mechanisms underlying lymphocyte lineage stability and plasticity remain elusive. Recent work indicates that innate lymphoid cells (ILC) possess substantial plasticity. Whereas natural ILC2 (nILC2) produce type-2 cytokines, plastic inflammatory ILC2 (iILC2) can coproduce both type-2 cytokines and the ILC3-characteristic cytokine, IL-17. Mechanisms that elicit this lineage plasticity, and the importance in health and disease, remain unclear. In this study we show that iILC2 are potent… Expand
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