Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

@article{Prokopec2016CuttingEM,
  title={Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.},
  author={Kajsa E Prokopec and Anna-Maria Georgoudaki and Silke Sohn and Fredrik Wermeling and Hans Gr{\"o}nlund and Emma Lindh and Michael C Carroll and Mikael C I Karlsson},
  journal={Journal of immunology},
  year={2016},
  volume={197 6},
  pages={
          2063-8
        }
}
Marginal zone macrophages (MZM) are strategically located in the spleen, lining the marginal sinus where they sense inflammation and capture Ag from the circulation. One of the receptors expressed by MZM is scavenger receptor macrophage receptor with collagenous structure (MARCO), which has affinity for modified self-antigens. In this article, we show that engagement of MARCO on murine macrophages induces extracellular ATP and loss of CD21 and CD62L on marginal zone B cells. Engagement of MARCO… CONTINUE READING
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SHOWING 1-10 OF 29 REFERENCES

Structure and function of the spleen

  • Nature Reviews Immunology
  • 2005
VIEW 12 EXCERPTS
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