Cutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responses.

@article{Tripathi2007CuttingEL,
  title={Cutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responses.},
  author={Pulak K. Tripathi and Thomas C. Mitchell and Fred D. Finkelman and David A Hildeman},
  journal={Journal of immunology},
  year={2007},
  volume={178 7},
  pages={4027-31}
}
During the acute T cell response most effector T cells die while some survive and become memory T cells. Selective expression of CD127 (IL-7Ralpha) on effector T cells has been proposed to engender their survival into the memory pool. We assessed the role of IL-7 in effector T cell survival using MHC class II tetramers to track a CD4+ T cell response following infection with a recombinant vaccinia virus (rVV-2W1S). Exogenous IL-7 prevented the contraction of the 2W1S-specific CD4+ T cell… CONTINUE READING

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