Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.

@article{Kortmann2015CuttingEI,
  title={Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin.},
  author={Jens Kortmann and Sky W. Brubaker and Denise M Monack},
  journal={Journal of immunology},
  year={2015},
  volume={195 3},
  pages={815-9}
}
Murine NLR family, apoptosis inhibitory protein (Naip)1, Naip2, and Naip5/6 are host sensors that detect the cytosolic presence of needle and rod proteins from bacterial type III secretion systems and flagellin, respectively. Previous studies using human-derived macrophage-like cell lines indicate that human macrophages sense the cytosolic needle protein, but not bacterial flagellin. In this study, we show that primary human macrophages readily sense cytosolic flagellin. Infection of primary… CONTINUE READING