Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK

@article{Gosling2000CuttingEI,
  title={Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK},
  author={J. Gosling and D. Dairaghi and Y. Wang and M. Hanley and D. Talbot and Z. Miao and T. Schall},
  journal={The Journal of Immunology},
  year={2000},
  volume={164},
  pages={2851 - 2856}
}
  • J. Gosling, D. Dairaghi, +4 authors T. Schall
  • Published 2000
  • Biology, Medicine
  • The Journal of Immunology
  • Searching for new receptors of dendritic cell- and T cell-active chemokines, we used a combination of techniques to interrogate orphan chemokine receptors. We report here on human CCX CKR, previously represented only by noncontiguous expressed sequence tags homologous to bovine PPR1, a putative gustatory receptor. We employed a two-tiered process of ligand assignment, where immobilized chemokines constructed on stalks (stalkokines) were used as bait for adhesion of cells expressing CCX CKR… CONTINUE READING
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