Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.

@article{Naradikian2016CuttingEI,
  title={Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.},
  author={Martin S Naradikian and Arpita Myles and Daniel P. Beiting and Kenneth J Roberts and Lucas A Dawson and Ramin Sedaghat Herati and Bertram Bengsch and Susanne L Linderman and Erietta Stelekati and Rosanne Spolski and Elaine Wherry and Christopher A Hunter and Scott E Hensley and Warren J Leonard and Michael P. Cancro},
  journal={Journal of immunology},
  year={2016},
  volume={197 4},
  pages={1023-8}
}
T-bet and CD11c expression in B cells is linked with IgG2c isotype switching, virus-specific immune responses, and humoral autoimmunity. However, the activation requisites and regulatory cues governing T-bet and CD11c expression in B cells remain poorly defined. In this article, we reveal a relationship among TLR engagement, IL-4, IL-21, and IFN-γ that regulates T-bet expression in B cells. We find that IL-21 or IFN-γ directly promote T-bet expression in the context of TLR engagement. Further… CONTINUE READING
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