Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation.

@article{Takemoto2006CuttingEI,
  title={Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation.},
  author={Naofumi Takemoto and Andrew M Intlekofer and John T. Northrup and Elaine Wherry and Steven L Reiner},
  journal={Journal of immunology},
  year={2006},
  volume={177 11},
  pages={7515-9}
}
Cytokines are critical determinants for specification of lineage-defining transcription factors of CD4+ T cell subsets. Little is known, however, about how cytokines regulate expression of T-bet and eomesodermin (Eomes) in effector and memory CD8+ T cells. We now report that IL-12, a signature of cell-mediated immunity, represses Eomes while positively regulating T-bet in effector CD8+ T cells during infection with Listeria monocytogenes. After resolution of infection and abatement of IL-12… CONTINUE READING
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