Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.

@article{Wortham2016CuttingEC,
  title={Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.},
  author={Brian W. Wortham and Bryan L. Eppert and Jennifer L. Flury and Sara Morgado Garcia and Walter R F Donica and Andrew Osterburg and Barbara Joyce-Shaikh and Daniel J. Cua and Michael T. Borchers},
  journal={Journal of immunology},
  year={2016},
  volume={196 8},
  pages={3227-31}
}
Chronic obstructive pulmonary disease (COPD) is a devastating disease with no effective therapies. We investigated the role of the C-type lectin receptor, CLEC5A, in macrophage activation and pulmonary pathogenesis in a mouse model of COPD. We demonstrate that CLEC5A is expressed on alveolar macrophages in mice exposed long-term to cigarette smoke (CS), as well as in human smokers. We also show that CLEC5A-mediated activation of macrophages enhanced cytokine elaboration alone, as well as in… CONTINUE READING
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