Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks1

@article{Anolik2008CuttingEA,
  title={Cutting Edge: Anti-Tumor Necrosis Factor Therapy in Rheumatoid Arthritis Inhibits Memory B Lymphocytes via Effects on Lymphoid Germinal Centers and Follicular Dendritic Cell Networks1},
  author={Jennifer H. Anolik and Rajan Ravikumar and Jennifer Barnard and Teresa Owen and Anthony Almudevar and Eric C. B. Milner and Chase H. Miller and Paul O. Dutcher and James A. Hadley and I{\~n}aki Sanz},
  journal={The Journal of Immunology},
  year={2008},
  volume={180},
  pages={688 - 692}
}
Rheumatoid arthritis (RA) is mediated by a proinflammatory cytokine network with TNF at its apex. Accordingly, drugs that block TNF have demonstrated significant efficacy in the treatment of RA. A great deal of experimental evidence also strongly implicates B cells in the pathogenesis of RA. Yet, it remains unclear whether these two important players and the therapies that target them are mechanistically linked. In this study we demonstrate that RA patients on anti-TNF (etanercept) display a… 
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