Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1

  title={Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1},
  author={Philip T Liu and Stephan R. Krutzik and Jenny Kim and Robert L. Modlin},
  journal={The Journal of Immunology},
  pages={2467 - 2470}
A major consequence of microbial infection is the tissue injury that results from the host inflammatory response. In acne, inflammation is due in part to the ability of Propionibacterium acnes to activate TLR2. Because all-trans retinoic acid (ATRA) decreases inflammation in acne, we investigated whether it regulates TLR2 expression and function. Treatment of primary human monocytes with ATRA led to the down-regulation of TLR2 as well as it’s coreceptor CD14, but not TLR1 or TLR4. The ability… 

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