Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1

@article{Liu2005CuttingEA,
  title={Cutting Edge: All-trans Retinoic Acid Down-Regulates TLR2 Expression and Function1},
  author={Philip T Liu and S. Krutzik and Jenny Kim and R. Modlin},
  journal={The Journal of Immunology},
  year={2005},
  volume={174},
  pages={2467 - 2470}
}
A major consequence of microbial infection is the tissue injury that results from the host inflammatory response. In acne, inflammation is due in part to the ability of Propionibacterium acnes to activate TLR2. Because all-trans retinoic acid (ATRA) decreases inflammation in acne, we investigated whether it regulates TLR2 expression and function. Treatment of primary human monocytes with ATRA led to the down-regulation of TLR2 as well as it’s coreceptor CD14, but not TLR1 or TLR4. The ability… Expand
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References

SHOWING 1-10 OF 24 REFERENCES
Review of the Innate Immune Response in Acne vulgaris: Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses
TLDR
Data suggest that P. acnes triggers inflammatory cytokine responses in acne by activation of TLR2, and that this receptor may provide a novel target for the treatment of this common skin disease. Expand
Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses1
  • T. Means, Bryan W. Jones, +6 authors M. Fenton
  • Biology, Medicine
  • The Journal of Immunology
  • 2001
TLDR
It is demonstrated that expression of a dominant negative TLR2 or TLR4 proteins in RAW 264.7 macrophages partially blocked Mtb-induced NF-κB activation, and E5531 could substantially block LPS- and Mt b-induced TNF-α production in both RAW 264,7 cells and primary human alveolar macrophage (AMφ). Expand
Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne
TLDR
Both Propionibacterium acnes and supernatants obtained from 72-h P. acnes cultures could induce significant concentrations of IL-1 beta, TNF-alpha, and IL-8 by both cell lines and by peripheral blood mononuclear cells as determined by enzyme-linked immunosorbent assay. Expand
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
TLDR
Investigation in leprosy provides evidence that regulated expression and activation of TLRs at the site of disease contribute to the host defense against microbial pathogens. Expand
Retinoids Inhibit Interleukin-12 Production in Macrophages through Physical Associations of Retinoid X Receptor and NFκB*
  • S. Na, B. Kang, +6 authors Tae Sung Kim
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1999
TLDR
It is proposed that retinoid-mediated suppression of the IL-12 production from LPS-activated macrophages may involve both inhibition of the NFκB-DNA interactions and competitive recruitment of transcription integrators betweenNFκB and RXR. Expand
Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages
TLDR
In macrophages from RARγ−/− mice, TTNPB still induced ABCA1, in association with marked upregulation of RARα, suggesting that high levels of R BARα can compensate for the absence of R ARγ, and a direct role of Rarγ/RXR in induction of macrophage ABCA 1 is indicated. Expand
Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
TLDR
In vivo administration of antibody to Tim-3 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and increases the number and activation level of macrophages. Expand
Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines
TLDR
Analysis of TLR expression in fractionated primary human leukocytes indicates that professional phagocytes express the greatest variety ofTLR mRNAs although several TLRs appear more restricted to B cells, suggesting additional roles for TLRs in adaptive immunity. Expand
Toll‐like receptors and the host defense against microbial pathogens: bringing specificity to the innate‐immune system
TLDR
The crucial role of TLRs for the host defense against infections has been strengthened recently by the description of patients partially defective in the TLR‐activation pathways. Expand
Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
TLDR
The LPS and LAM receptors share CD14, LBP, and a putative endotoxin antagonist-inhibitable signal transducing component, however, the LAM signaling system appears to require an additional receptor component whose expression is restricted to cells of hemopoietic origin. Expand
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