Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation.

@article{Beuneu2011CuttingEA,
  title={Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation.},
  author={H{\'e}l{\`e}ne Beuneu and Jacques Deguine and Isabelle Bouvier and James P Di Santo and Matthew L Albert and Philippe Bousso},
  journal={Journal of immunology},
  year={2011},
  volume={187 5},
  pages={2084-8}
}
NK cells are cytotoxic lymphocytes that are most efficient at fulfilling their functions after a phase of priming provided by cytokines and/or accessory cells. Although type I IFNs are known to be important in this process, it remains unclear whether they act directly on NK cells or indirectly on accessory cells. We used adoptive transfer experiments and mixed bone marrow chimeras to dissect the requirement for type I IFN signaling in response to the dsRNA analog polyinosinic-polycytidylic acid… CONTINUE READING
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