Cutaneously applied 4-hydroxytamoxifen is not carcinogenic in female rats.

  title={Cutaneously applied 4-hydroxytamoxifen is not carcinogenic in female rats.},
  author={F Sauvez and Denis Drouin and Mohamed Hbib Ben Attia and H. Bertheux and Roy P. Forster},
  volume={20 5},
Tamoxifen is widely used to treat oestrogen-dependent carcinoma of the breast. Previous long-term studies have shown that oral administration of tamoxifen induces hepatoproliferative lesions and hepatocellular tumours in rats. 4-hydroxytamoxifen is an active metabolite of tamoxifen undergoing clinical evaluation for the treatment of various non-malignant breast diseases by topical application. In the present study, 4-hydroxytamoxifen was administered daily by cutaneous application for 101 weeks… CONTINUE READING
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