Cutaneous side effects of inhibition of VEGF signal transduction.

  title={Cutaneous side effects of inhibition of VEGF signal transduction.},
  author={Gottfried Wozel and M Sticherling and Michael P Sch{\"o}n},
  journal={Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG},
  volume={8 4},
The VEGF signaling pathway (including ligands, surface-bound receptors and intracellular downstream signaling cascades) is critically involved in angiogenesis under normal and pathological conditions, in particular in malignant tumors. As a consequence, several therapies that target specific components of this pathway have been approved for clinical use or are in various stages of clinical development. Currently, the monoclonal antibodies bevacizumab and ranibizumab, as well as the small… CONTINUE READING
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