Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6 null mice.

@article{Nishimura2000CutaneousMI,
  title={Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6 null mice.},
  author={Noriko Nishimura and Vivienne Elizabeth Reeve and Hiroyuki Nishimura and Masataka Satoh and Chiharu Tohyama},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={114 2},
  pages={343-8}
}
The mediators of cutaneous metallothionein induction by ultraviolet radiation have not been defined. In this study we sought to identify cytokines that might be involved. We examined the role of interleukin-6, using the IL-6 null (IL-6-/-) mouse, which has been observed to be highly sensitive to ultraviolet radiation damage. Whereas cutaneous metallothionein concentration, measured by radioimmunoassay, began to rise in wild-type (IL-6+/+) mice by 12 h after ultraviolet irradiation, there was a… CONTINUE READING