Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?

  title={Cutaneous malignancies simulating seborrheic keratoses: An underappreciated phenomenon?},
  author={Tiffany Y Chen and Annie O. Morrison and Clay J Cockerell},
  journal={Journal of Cutaneous Pathology},
  pages={747 - 748}
Seborrheic keratosis (SK), a common and benign entity, is generally diagnosed clinically without the need for a biopsy. Given their variable appearance, SK may mimic cancer clinically and require biopsy for clinically equivocal cases. A clinician may also choose to perform biopsies on SK based on other circumstances, such as cosmetic reasons or SK being in an inconvenient and irritative location. 
Basaloid tumors arising from seborrheic keratosis: Malignant basal cell carcinoma or benign basaloid follicular hamartomatous proliferation?
Basaloid tumors arising from seborrheic keratosis (SK) that resembled basal cell carcinoma (BCC) were infrequently observed in our patients. They also exhibited morphologic features similar to those
Morphologic Mimickers of Seborrheic Keratoses: Cutaneous Lesions Masquerading as Seborrheic Keratoses
If a patient presents with a presumptive seborrheic keratosis that has changed in appearance and for which malignancy is also suspected, a biopsy may be helpful for diagnostic clarification.
A Successful Defect Closure After Total Excision of Seborrheic Keratoses with Atypical Clinical Presentation Using Island Pedicle Flap in an Elderly Patient
IPF is an appropriate method for defect closure in an elderly patient after facial total tumor excision due to its ability to restore the natural contour and texture match by utilizing cheek laxity, without interfering the nasolabial fold.
Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses
Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK, and promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed.
Clinical spectrum of cutaneous melanoma morphology
Case Study
  • N. Russell
  • Medicine
    Journal of the Dermatology Nurses' Association
  • 2020


Melanoma within the seborrheic keratosis.
A patient with a clinically typical-appearing SK is described, which was biopsied and histologically proven to be a malignant melanoma arising in the SK, a reminder that the reliability of clinical diagnosis of SKs needs to be questioned.
Are All Seborrheic Keratoses Benign? Review of the Typical Lesion and Its Variants
Although all subtypes of SK are benign, their association with other malignant lesions and ability to serve as cutaneous markers of internal malignancy emphasize the importance of correctly identifying all variants.
Basal cell carcinoma showing surface hyperkeratosis clinically mimicking seborrheic keratosis
This case indicates that dermatologists should inspect all visible body surfaces, including face and neck, especially in Asian patients, and suppose that PF on the right lower back in this case should be associated with BHDS.
Clinical misdiagnosis of squamous cell carcinoma in situ as seborrheic keratosis. A prospective study.
Malignant transformation of seborrheic keratoses, although rare, appears to occur more frequently in the elderly on the head and neck, suggesting the role of cumulative sun damage in the transformation of such lesions.
Cutaneous Horn Malignant Melanoma
A 73-year-old Japanese woman presented with cutaneous horn on the right cheek, which showed exophytic growth with marked papillomatosis and Histopathology showed proliferation of atypical melanocytes with melanin pigments in the epidermis and dermis under the cutaneous Horn.
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors
It is concluded that KA is not a variant of SCC, but a benign and frequently regressing proliferative lesion or borderline neoplasm, although there is the potential for SCC to arise within KA.
Verrucous naevoid and keratotic malignant melanoma: a clinico‐pathological study of 20 cases
It is important for surgical pathologists to recognize Verrucous naevoid malignant melanoma, as it may be confused both clinically and pathologically with benign lesions.
Seborrheic keratosis: reflectance confocal microscopy features and correlation with dermoscopy.
Malignant neoplasms associated with seborrheic keratoses. An analysis of 54 cases.
The term compound tumor is proposed to designate the finding of two distinctive neoplasms either directly contiguous with each other or immediately adjacent to each other in this association of malignant neoplasm.
Early detection of malignant melanoma: The role of physician examination and self‐examination of the skin
The combination of routine physician examination of the skin coupled with self-examination provides a realistic opportunity for the identification of early malignant melanomas. Removal of such thin