Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

@article{Fuhlbrigge1997CutaneousLA,
  title={Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells},
  author={R. Fuhlbrigge and J. Kieffer and D. Armerding and T. Kupper},
  journal={Nature},
  year={1997},
  volume={389},
  pages={978-981}
}
T cells play a pathogenic role in many inflammatory and certain malignant skin diseases, including psoriasis, atopic and allergic contact dermatitis, and cutaneous T-cell lymphoma. Memory T cells that infiltrate the skin express a unique skin-homing receptor called cutaneous lymphocyte-associated antigen (CLA), a carbohydrate epitope that facilitates the targeting of T cells to inflamed skin. CLA is defined by both its reactivity with a unique monoclonal antibody, HECA-452, and its activity as… Expand
Skin homing T cells.
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
Targeting the cutaneous lymphocyte antigen (CLA) in inflammatory and neoplastic skin conditions
The role of skin-homing T cells in extrinsic atopic dermatitis.
The HECA‐452 epitope is highly expressed on lymph cells derived from human skin
Regulation of Allergic Inflammation by Skin–Homing T Cells in Allergic Eczema
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