Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

@article{Fuhlbrigge1997CutaneousLA,
  title={Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells},
  author={R. Fuhlbrigge and J. Kieffer and D. Armerding and T. Kupper},
  journal={Nature},
  year={1997},
  volume={389},
  pages={978-981}
}
T cells play a pathogenic role in many inflammatory and certain malignant skin diseases, including psoriasis, atopic and allergic contact dermatitis, and cutaneous T-cell lymphoma. Memory T cells that infiltrate the skin express a unique skin-homing receptor called cutaneous lymphocyte-associated antigen (CLA), a carbohydrate epitope that facilitates the targeting of T cells to inflamed skin. CLA is defined by both its reactivity with a unique monoclonal antibody, HECA-452, and its activity as… Expand
CD43 is a ligand for E-selectin on CLA+ human T cells.
TLDR
The identification and characterization of CD43 as a T-cell E-selectin ligand distinct from PSGL-1 expands the role ofCD43 in the regulation of T- cell trafficking and provides new targets for the modulation of immune functions in skin. Expand
Skin homing T cells.
TLDR
It has been proposed that differential organ-specific trafficking of CD4+ Th1 and Th2 cells promote different inflammatory reactions, and CLA expression predominantly reflects the regulated activity of the glycosyltransferase, FucT-VII. Expand
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
TLDR
It is suggested that 1,25D(3) can selectively downregulate CLA expression without influencing lymphocyte migration patterns to other tissues. Expand
Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin.
TLDR
4-F-GlcNAc was directly incorporated into native CLA expressed on T cells, indicating direct inhibition on poly-N-acetyllactosamine elongation and selectin-binding determinants on PSGL-1 O-glycans and establish a potential treatment approach for targeting pathologic lymphocyte trafficking to skin. Expand
Targeting the cutaneous lymphocyte antigen (CLA) in inflammatory and neoplastic skin conditions
TLDR
Cutaneous lymphocyte antigen is a potential molecular target for both systemic and skin-directed therapy for cutaneous T-cell lymphomas and is the essential para-physiological mechanism enabling immune surveillance of tissues for tumors as well as effector cell recruitment to inflammatory sites. Expand
Neutrophils, monocytes, and dendritic cells express the same specialized form of PSGL-1 as do skin-homing memory T cells: cutaneous lymphocyte antigen.
TLDR
It is hypothesized that the types of circulating leukocytes discussed above all use CLA/PSGL-1 to tether and roll on E- and P-selectin along the vascular endothelium. Expand
The role of skin-homing T cells in extrinsic atopic dermatitis.
TLDR
In EAD patients, CLA+ T cells express increased levels of markers associated with activation, adhesion and apoptosis, show differences in the level of expression of differentiation markers and display a distinct chemokine receptor preference, compared with cells from healthy controls. Expand
Tonsillar B Cells Do Not Express PSGL-1, but a Significant Fraction Displays the Cutaneous Lymphocyte Antigen and Exhibits Effective E- and P-Selectin Ligand Activity
TLDR
The observations suggest that several adhesion molecules may be involved in B cell homing which include CLA, the P-selectin ligand, and structures such as α4β7. Expand
The HECA‐452 epitope is highly expressed on lymph cells derived from human skin
TLDR
UV irradiation of the skin and induction of an allergic contact dermatitis did not change CLA expression on lymph cells, although lymph flow and cell output increased, providing further evidence for an important role of CLA in cell homing to the skin. Expand
Regulation of Allergic Inflammation by Skin–Homing T Cells in Allergic Eczema
TLDR
The results indicate that in–vivo–activated both CD4+ and CD8+ memory/effector T cells with skin–homing property play a specific and decisive role in the pathogenesis and exacerbation of AD. Expand
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References

SHOWING 1-10 OF 26 REFERENCES
Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen.
TLDR
Heterogeneity in the regulation of HR expression on antigen-specific T cells may play a role in determining sites of involvement in tissue-directed allergic responses, as compared with nonatopics or allergic patients without skin involvement. Expand
Skin disease‐related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E‐selectin but not P‐selectin binding
TLDR
It is concluded that in sensitized individuals, antigen‐specific T cells expressing high levels of CLA localize in skin promptly after epicutaneous challenge and that T cells can interact with P‐selectin on endothelium and that S‐Lex does not appear to be necessary for this interaction. Expand
A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites.
TLDR
Among lymphocytes, the preferential expression of the HECA-452 determinant by cutaneous T cells supports the hypothesis that the skin constitutes a immunologically unique lymphoid tissue and suggests that this molecule may play a role in either lymphocyte homing to skin or in lymphocyte interactions with the epidermis. Expand
ELAM-1 is an adhesion molecule for skin-homing T cells
TLDR
It is concluded that at sites of chronic inflammation, ELAM-1 may function as a skin vascular addressin, a tissue-selective endothelial cell-adhesion molecule for skin-homing memory T lymphocytes. Expand
The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1
TLDR
Evidence is presented that CLA itself is the (or a) lymphocyte homing receptor for ELAM-1, an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Expand
Cutaneous lymphocyte antigen-positive T lymphocytes preferentially migrate to the skin but not to the joint in psoriatic arthritis.
TLDR
The distinct pattern of T cell infiltration into sites of inflammation within the skin and synovium is regulated by both organ-specific homing and general inflammation-related mechanisms. Expand
Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production
TLDR
The data suggest that bacterial toxins induce the expansion of skin-homing CLA+ T cells in an IL-12-dependent manner, and thus may contribute to the development of skin rashes in superantigen-mediated diseases. Expand
Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1).
The cutaneous lymphocyte-associated Ag (CLA) is expressed by a subset of circulating memory/effector T cells and by the vast majority of skin-infiltrating T cells. CLA is thought to targetExpand
Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites
TLDR
Tissue microenvironments play a major role in determining the character of local T cell infiltrates via their ability to import and retain memory/effector subsets selectively or, more generally, depending on the intensity of local inflammatory stimuli. Expand
Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells.
TLDR
The development of the CLA+ memory T cell subset is likely a product of the cumulative experience of those T cells with respect to local microenvironments at previous sites of activation, perhaps involving differential availability of bioactive TGF-beta 1 and/or IL-6 (both cytokines produced in skin). Expand
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