Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids.

@article{Lange2000CutaneousIA,
  title={Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids.},
  author={Kornelia Lange and Burkhard Kleuser and Anja Gysler and Michael Bader and Catarina Maia and Claus Scheidereit and Hans Christian Korting and Monika Sch{\"a}fer-Korting},
  journal={Skin pharmacology and applied skin physiology},
  year={2000},
  volume={13 2},
  pages={93-103}
}
The nonhalogenated double ester of prednisolone, prednicarbate (PC), is the first topical glucocorticoid with an improved benefit/risk ratio verified clinically and in vitro. To evaluate if this is due to unique characteristics of this steroid, a new compound created according to an identical concept, prednisolone 17-ethylcarbonate, 21-phenylacetate (PEP), and the new halogenated monoester desoximetasone 21-cinnamate (DCE) were tested and compared to PC, desoximetasone (DM) and betamethasone 17… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Investigations of in vitro Test Systems for the Detection of Glucocorticoid-induced Skin Atrophy as a Tool in Drug Discovery

H C Christoph Markschies, Schön Lutz-Helmut, +9 authors Erich Schoepe
2009
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…